Hasani has a serious genetic disorder — sickle cell anemia — that threatens multiple complications, including severe pain, organ damage and iron overload. Throughout the years, specialists at Children’s have helped Hasani manage his illness and weather its storms.
Hematology/Oncology
DIAGNOSES AND CONDITIONS TREATED
Acquired hemostatic disorders and genetic disorders
• Hemophilia
• Hemophilia variants
• Inhibitor patients
• von Willebrand’s disease
Anemia: Evaluation and treatment of anemias
• Nutritional anemia
• Genetic anemia
• Sickle cell syndromes
• Thalassemia syndromes
• Enzyme defects
• Membrane disorders
• Immune disease
• Anemia associated with other illness or infection
Bone tumors
A multidisciplinary team of oncologists, orthopedic surgeons, psychiatrists, and pathologists provide advanced treatment for all bone tumors, including:
• Osteogenic sarcoma
• Ewing’s sarcoma
• Primitive neuroectodermal tumor (PNET) of all stages
Our multi-modal approach may include chemotherapy, radiation, and surgery designed to preserve limb function.
Central nervous system malignancies
A multidisciplinary team of surgeons, oncologists, physiatrists, and radiation physicians provides comprehensive diagnosis and treatment for all brain lesions. These include low-grade and high-grade cerebral, cerebellum, brain stem, or spinal tumors. Specific tumors include astrocytomas, medulloblastoma, brain stem glioma, ependymomas, optic gliomas, craniopharygiomas, and germ cell tumors.
Evaluation and treatment of bleeding, bruising, and petechiae or clotting
Germ cells, tumors, teratomas
Histocytic disorders
• Histocytosis
• Virus-associated histocytosis
• Familial lymphohistocytosis
Iron disorders
• Iron deficiency
• Transfusional iron overload
• Neonatal and juvenile genetic hemochromatosis
Lead-related disorders
Liver tumors
• Hepatoma
• Hepatoblastoma
• Hemangioma
• Hepatocellular carcinoma
Neonatal disorders
• Evaluation and treatment of anemia, neutropenia, thrombocytopenia, coagulation disorders, and polycythemia in pre-term and term births
• Prenatal and neonatal consultation for families at risk for genetic or maternal-related hematological disorders, including immune anemias (Rh, ABO disorders), genetic anemias, immune thrombocytopenia, hereditary bleeding, and thrombotic diseases
• Evaluation of neonatal masses (lymphadenopathy, splenomegaly, hemangioma, swellings)
Neuroblastoma
Diagnosis and treatment of low-risk and high-risk patients, including relapsed patients and transplantation candidates
Platelet disorders
• Thrombocytopenia (immune ITP, secondary thrombocytopenia, drug-induced thrombocytopenia, infection, and genetic disorders)
• Thrombocytosis
• Qualitative platelet dysfunction
Quantitative neutropenia and qualitative white cell disorders
Retinoblastoma and eye tumors
Screening, staging, and treatment is provided by a team of specialists, including oncology-related ophthalmologists.
Rhabdomyosarcoma and soft tissue tumors
We provide diagnosis and treatment based on staging, pathology, and anatomic site. General principles of treatment integrate selective surgery, radiotherapy, and chemotherapy. Specialized care is provided for patients with metastases, recurrent disease, and advanced progression.
Thrombotic disorders
• Genetic disorders (antithrombin 3, protein C, protein S), acquired disorders (antiphospholipid syndrome)
• Venous thrombosis
• Arterial thrombosis
• Thrombolytic therapy
Tumors, cancer, masses
We are a nationally recognized cancer center and a participating member of the Children’s Oncology Group. Our program, supervised by James Feusner, MD, provides immediate diagnosis and treatment of any child with a potential tumor or cancer. We commonly receive referrals for children with lymphadenapathy, splenomegaly, and abdominal masses in order to determine their origin and causes.
We have a multidisciplinary tumor group that includes pathologists, surgeons, oncologists, radiation therapists and bone marrow transplant physicians. A bi-weekly multidisciplinary tumor board meets to make recommendations for each patient.
We also provide counseling, education, and monitoring of treated children for late effects of treatment. The specific disorders we treat include:
• Lymphoproliferative disorders, myelodysplastic syndromes, pan-neoplastic syndromes, pre-leukemia syndromes
• Acute leukemias (acute lymphoblastic leukemia, acute myeloblastic leukemia, and other subtypes, including undifferentiated and mixed lineage, refractory leukemia)
• Chronic leukemias (adult type chronic myelogenous [Ph positive], juvenile myelomonocytic leukemia, acute blast phase of chronic leukemia, neonatal leukemia)
• Hodgkin’s disease: diagnosis, staging, chemotherapy, radiation, surgery and transplantation
• Non-Hodgkin’s lymphoma (including all subtypes: b-cell, t-cell, low grade-high grade, Stages I – IV)
Wilm’s tumors
We provide sophisticated diagnosis and treatment options for kidney tumors, including cytogenetic and molecular classification. We also offer specific therapy for nephroblastomatosis or mesoblastic nephroma, which is distinct from Wilm's tumor.
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